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The fact that the best-fitting model was quadratic rather than strictly linear is itself informative: it suggests that pushing the dose to 6.0 mg did not buy additional histologic benefit and may have shifted the tolerability balance, exactly the kind of nuance a dose-finding trial exists to surface

December 18, 2024: FDA Updates Ozempic Warning Label to Include Pulmonary Aspiration as Adverse Reaction The FDA updated the warning label for Ozempic, the GLP-1 drug used to treat diabetes and lose weight

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One promising option is a modern version of an older technique

Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, et al