MOTS-C is interesting because the signal points toward: Better mitochondrial output per unit of fuel Improved cellular stress handling More efficient energy use inside muscle tissue A pathway that may overlap with exercise adaptation rather than replace it The study also ties MOTS-C to PGC-1 and AMPK , two of the most important nodes in metabolic biology
10.3389/fphar.2022.964399 38 Prasad-ReddyL.IsaacsD
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doi: 10.3389/fmed.2026.1761721 Received 09 December 2025 Revised 12 January 2026 Accepted 26 January 2026 Published 20 February 2026 Volume 13 - 2026 Edited by Constantin Caruntu, Carol Davila University of Medicine and Pharmacy, Romania Reviewed by Mahmood Ahmed, University of Education Lahore, Pakistan Mohammad Amin Raeisi Estabragh, Kerman Medical University, Iran Updates Copyright 2026 Sanlier, Sacinti, Turkoglu and Sanlier
