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When you stop supplementing, the liver has less "fuel" for these Phase II pathways

Some integrative practitioners use IV glutathione which can increase glutathione levels for a short time, but since the IVs are not done daily, it is difficult to keep glutathione levels elevated

Wang, D., Guo, K., Zhu, Y., Sun, J., Dreglea, A., & Yu, J

Moreover, TDNPs have been verified to activate the Nrf2/HO-1 signaling pathway to promote the proliferation and migration of fibroblasts by improving their endogenous antioxidant capacity and reducing cell apoptosis [40]

Combined with L-serine & P5P B6, it helps enable the transsulfuration pathway required for glutathione production allowing homocysteine byproducts to be processed, not just recycled