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Mounjaro (tirzepatide) activates both GLP-1 and GIP receptors, offering a dual-pathway mechanism that may enhance appetite regulation and metabolic response in certain patients

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The literature was searched in PubMed/MEDLINE, Embase, Web of Science, and Google Scholar from database inception to 10 March 2026, using terms related to knee osteoarthritis, obesity, GLP-1 receptor agonists, incretin-based therapies, GLP-1 receptor biology, pharmacology, molecular mechanisms, inflammatory signaling, NF-B, NLRP3 inflammasome, macrophage polarization, weight loss, arthroplasty, perioperative management, sarcopenia, safety, and cost-effectiveness