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Xu MQ, Cao HL, Wang WQ, et al

This interaction can increase the recruitment of RNA polymerase II and other transcription factors to promoter regions, thereby promoting the transcription of target genes

High NNMT activity has also been linked to: Poor mitochondrial function Increased oxidative stress Accelerated fat storage Inhibiting this enzyme helps reverse those metabolic imbalances

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This specific sequence was first isolated from human plasma in the 1970s, making it a naturally occurring compound that the body already recognizes and utilizes