These molecules act as signals that recruit inflammatory cells, including neutrophils and macrophages, to the site of cell death, exacerbating local inflammation and potentially contributing to miscarriage ( 5.3 Evidence of ferroptosis in RM pathophysiology Emerging studies support the involvement of ferroptosis in RM, highlighting its potential role in pathophysiology through various lines of evidence
However, exhaustion or reduced activity of caspase-8 shifts cellular fate from apoptosis towards necroptosis (Leeper, 2016
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Moreover, the clinical translation of pharmacological agents targeting mitochondrial function and energy metabolism remains limited, highlighting the need for further investigation in both preclinical and clinical settings
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