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Tirzepatide: Even greater reductions, averaging 2.0-2.3 percentage points

Clinicians should also consider alternative medical explanations for new-onset fatigue, including thyroid dysfunction, anemia, sleep apnea (which may improve or persist despite weight loss), chronic kidney disease, or cardiovascular conditions

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Decreased consumption of branched-chain amino acids improves metabolic health

Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH