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According to FDA labeling and American Diabetes Association guidelines, GLP-1 receptor agonists are indicated for type 2 diabetes (as an adjunct to diet and exercise) and for chronic weight management in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity

These are not chronic conditions

55 Other studies confirm results around 15% average loss over 68 weeks

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Data on glycated hemoglobin reduction and weight loss show a levelling off at the 1.5 mg and 1.0 mg dose respectively with only a small clinical benefit reported with the higher doses [19]