While GLP-1 and GIP do similar things for blood sugar control and fat metabolism as tirzepatide, retatrutide also activates GCG which primarily benefits gut health and nutrient absorption
Insufficient protein during rapid weight loss leads to muscle wasting, which worsens fatigue, reduces metabolic rate, and produces the "skinny fat" outcome nobody wants
Best for: Loose abdominal skin Crepey upper arms or thighs Overall texture and tone improvement on larger body areas EMSCULPT NEO: Build Muscle, Burn Fat, Restore Definition Many GLP1 patients lose some muscle mass alongside fat, which can contribute to a softer, less defined shape or a skinny fat appearance
The main difference between oral and injectable semaglutide is how it enters the body, not what it does once its there
Another recently published review (Wu et al., BMC Medicine, 2025 ) looked at a range of studies on this subject to provide an overview of what happens when these medications are stopped