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To mimic the trimerized conformation of the native SARS-CoV-2 spike glycoprotein more closely, they fused naturally trimerized human resistin to the spike ectodomain to generate a stable trimer protein antigen called SmT1

It is important to check distal pulses and the ankle-brachial index to exclude vascular claudication

That distinguishes it sharply from tirzepatide, and it means every figure quoted for CagriSema comes from a clinical trial rather than an approved label