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Common presentations include: Persistent fatigue and general malaise Discomfort or dull aching in the upper right abdomen Weakness and reduced stamina As the disease progresses to more advanced stages, such as cirrhosis (severe scarring), additional symptoms may emerge including jaundice (yellowing of skin and eyes), fluid retention in the abdomen (ascites), easy bruising, and confusion

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Nanoparticle-encapsulated Curcumin inhibits diabetic neuropathic pain involving the P2y12 receptor in the dorsal root ganglia

J Biol Chem 283:3561435621 [DOI] [PMC free article] [PubMed] [Google Scholar] Terman GW, Jin W, Cheong YP, Lowe J, Caron MG, Lefkowitz RJ, Chavkin C

The compounding factor: time plus temperature Degradation is not just about temperature