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Decrease in Serum Bicarbonate In a study of concomitant therapy of 10 mg dapagliflozin with exenatide extended-release (on a background of metformin), four patients (1.7%) on concomitant therapy had a serum bicarbonate value of less than or equal to 13 mEq/L compared to one each (0.4%) in the dapagliflozin and exenatide-extended release treatment groups

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Br J Pharmacol 153 (Suppl 1):S298S309

Accessed November 26, 2017

Prospective studies will be needed to determine whether semaglutide truly increases the risk of NAION, and whether certain formulations, doses, or patient groups are particularly vulnerable