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TGF- is an immune compound that contributes to cellular changes and tissue fibrosis

(2022) showed that Smad 2/3 and stratifin proteins play a detrimental role in CP-induced AKI by inducing necroptosis and necroinflammation, and interestingly, targeting these proteins suppressed the necroptosis signaling and thereby alleviating AKI

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Therefore, l-ARG supplementation might be regarded to as a potential alternative approach in a variety of clinical settings, spanning different therapeutic requirements in the management of ED

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