In addition, several microvascular alterations have long been associated with AD neuropathology, including increased atherosclerotic lesions, capillary tortuosity and rarefaction, thickening of the basement membrane and, in some cases, string vessels, which lack endothelial cells [103,150,151,152]
A small pilot study using prospective data from 13 women, between 6683 years, living with obesity and prescribed orlistat, found weight loss of 9.4% over 6 months [105]
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This observation reflects a long-term cancer risk association rather than a treatment-emergent adverse effect profile, and detailed adverse event data were not reported in the cited study
ZJJ, KB, HYJ, and YYB analyzed the data and wrote the manuscript