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When to Consult Your Healthcare Provider About GLP-1 Side Effects While constipation from GLP-1 medications is common, certain symptoms warrant medical attention: Severe abdominal pain Blood in stool Unexplained weight loss, hard to tell when youre on GLP-1s though Constipation that alternates with diarrhea Symptoms that persist despite lifestyle changes and over-the-counter remedies Constipation that begins suddenly and represents a significant change Your healthcare provider might: Adjust your GLP-1 medication dosage Recommend prescription medications for constipation Evaluate for other potential causes of constipation Consider temporarily pausing treatment if symptoms are severe Balancing Benefits and Side Effects of GLP-1 Weight Loss Drugs For many patients, the benefits of GLP-1 medications for weight loss or diabetes management outweigh the inconvenience of constipation