The approach taken by retatrutide to target multiple gut hormones makes sense, said Dr
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Key characteristics: Delayed gastric emptying Food remains in the stomach for hours (or days) Difficulty digesting normal meals Chronic nausea and vomiting Nutritional deficiencies and dehydration In severe cases, patients cannot tolerate solid foods and may require long-term medical management
Because weak carbonic-anhydrase inhibition can precipitate non-anion-gap metabolic acidosis, caution or avoidance is warranted in patients with chronic metabolic acidosis, severe pulmonary disease with chronic hypercapnia, or conditions pre-disposing to osteoporosis, nephrolithiasis, or nephrocalcinosis
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