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Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
A placebo controlled, dose escalating trial established various pharmacokinetics and dynamics parameters of oral semaglutide (prepared with SNAC), carried out on 2 groups (6 healthy males in each)
rodents possess a high density of GLP-1 receptors in their thyroid C-cells, which leads to hyperplasia and tumors when stimulated
Documented Heart Rate Increases : As noted in FDA prescribing information, semaglutide can increase resting heart rate by an average of 1-4 beats per minute, with some patients experiencing greater increases
It has been approved for weight management under the brand name Wegovy
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