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This has been reported with both tirzepatide and retatrutide, though it is likely related to the weight loss itself rather than the medication directly

This healing and regenerative peptide has also been studied in wound repair, where it appears to support angiogenesis (new blood vessel formation) and the recruitment of immune cells such as macrophages to damaged tissue

This is desirable when a substantially non-fluid or substantially viscous formulation is needed

This gap has practical implications

Common causes include pernicious anaemia (autoimmune condition), plant-based diets without supplementation, gastrointestinal surgery, and long-term use of metformin or proton pump inhibitors