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Smoking is often preferred for social situations or quick relaxation, offering immediate effects that allow users to control their dosage with ease

Archaeological evidence suggests that tobacco cultivation dates back to at least 14001000 BCE in regions such as Mexico and the Mississippi Valley

Analyzing the effects on gene expression and DNA methylation that are shared between smoking and aging, the researchers noted that in people who quit smoking, non-reversible DNA methylation sites in the lung were enriched in DNA methylation sites that are associated with aging signatures, but this wasnt the case for reversible and partially reversible sites suggesting that the smoking effects that affect DNA methylation in common to aging are more persistent in time. This was not the case for gene expression changes

Smoking is not just a habit

Reg Stud Mar Sci 46:101902