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Aging: As you grow older, the skin gets thinner and the blood vessels under your eyes, known as the lists, become more visible, giving the appearance of black eyes

Bak DH, Choi MJ, Kim SR, Lee BC, Kim JM, Jeon ES, Oh W, Lim ES, Park BC, Kim MJ, et al

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The sustained accumulation of ROS and the ROS-induced buildup of lipid peroxides further compromises the integrity of the plasma membrane, and ultimately, the cell will die due to ferroptosis

Wakabayashi, N., et al., Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation