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GLP-1 signalling can influence keratinocyte function, immune cell activity and wound healing, and modulates intracellular pathways including cAMP/PKA, AMPK, PI3K/Akt and NF-B, as well as immune axes such as IL-23/Th17/IL-17 and inflammasome-related signalling

If required the dose can be escalated after four weeks by a further 5 milligrams to 10 or 15 milligrams weekly

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North American Association for the Study of Obesity ( NAASO ) Abstract (2007)

This results in a series of effects across metabolic pathways that contribute to appetite suppression and potentially an increase in energy expenditure