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GDH1 transcriptional regulation and phase-specific degradation of Gdh1 protein The regulation of GDH1 under glucose conditions is performed by nitrogen catabolite repressor (NCR)-sensitive activators, Leu3p and activators exclusive for respiratory growth such as the HAP complex that coordinates nuclear and mitochondrial gene expression [21, 25, 26]

We also hypothesize that GLP-1 axons that are apposed to GLP-1R-negative SPNs may regulate these cells directly via synaptic glutamate release 58,59 , and indirectly by GLP-1 release that might modulate the activity of nearby GLP-1R + terminals on the surface of SPNs 60

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