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A meta-analysis of 37 randomized controlled trials found approximately 2,000 mg/day oral L-Carnitine yields modest weight-loss effects (~1.2 kg), with diminishing returns above that dose [2]

doi: 10.1016/j.regpep.2012.08.009 21 CamilleriMVazquez-RoqueMIturrinoJBoldinghABurtonDMcKinzieSet al

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He also pointed out the higher dose led to a greater incidence of dysasesthesia a condition characterized by abnormal pain sensations which he said as far as I am aware are a relatively new adverse event with this class of compounds and deserves further investigation, including further evaluation of nerve conduction studies to ensure that there is no adverse effect on peripheral sensory nerves. Camilleri noted evidence that GLP-1 receptors are present on peripheral sensory nerves as additional justification to thoroughly evaluate safety data related to sensory nerve function

Next, 2 L of the 2nd supernatant was mixed with 198 L of internal standard and centrifuged at 20,000 g , 0 C for 5 min