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A small randomized study (9) with N=60 patients where melatonin was orally administrated (3mg/day) from day 3-5 until hCG administration (oocyte collection) showed: a higher number of total oocytes (11.5 vs 6.9) higher number of mature oocyte (9% vs 4.4%) a higher rate of embryos transferred (69.3% vs 44.8%) These results were confirmed in another independent trial (10)

however, Cu/Zn-SOD knockout mice were found to be expected and show changes only after traumatic injury [82]

Hui Tang: Writing review & editing, Investigation

ALC was administered at two doses (500 or 1,000 mg) three times a day (t.i.d.) for 1 year

doi: 10.1016/j.tips.2010.06.006