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By applying multivariate regression adjusting for known genetic and nongenetic dose predictors, they also detected genome-wide significance of p A (-28% per allele), body surface area (BSA) (+11% per 0.25 m 2 , CYP2C9*3 (-33% per allele), CYP2C9*2 (-19% per allele), age (-7% per decade), target INR (+11% per 0.5 unit increase), amiodarone use (-22%), smoker status (+10%), race (-9%), and current thrombosis (+7%)