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doi: 10.1038/s41467-024-49133-z 370 WangR.LanC.BenlaghaK.CamaraN

Clinical trials have consistently demonstrated that semaglutide treatment is associated with reductions in total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides, along with small and sometimes variable changes in high-density lipoprotein cholesterol (HDL-C)

From the perspective of oral GLP-1 drug development trends, these developments signal a critical turning point for pharmaceutical innovation and global drug supply

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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis