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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts
This localized approach allows the peptide to target the injured tissues directly, enhancing the healing process
Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation 15,19
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Similarly, mutations in p62 result in decreased elimination of misfolded and ubiquitinated proteins (Yue and Yang, 2013)
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