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Product-Quality Risks Incorrect amino-acid sequence Free peptide supplied as an undeclared salt Incorrect acetate content Incorrect net peptide quantity Deletion or insertion sequences Oxidation of the tryptophan residue Hydrolytic degradation Peptide aggregates or complexes Residual synthesis reagents Residual solvents Unverified bacterial-endotoxin control Unverified microbiological quality Certificates unrelated to the supplied batch Damage during uncontrolled storage or transport Limited adverse-event reports do not establish safety A product without widespread regulated clinical use will not generate a mature pharmacovigilance database

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First to go was glutamate aka MSG following the principles of the Reduced Excitatory Inflammatory Diet (REID references can be found here ) developed by PhD biochemist Dr Katherine Reid

The systematic review in PubMed analysed 11 studies with a total of 805 subjects