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The candidate previously demonstrated promising weight loss outcomes in Phase 2 trials, and its progression into late-stage testing underscores the competitive momentum building in this high-growth therapeutic category In January 2024, Zealand Pharma and Boehringer Ingelheim announced positive Phase 2 results for BI 456906, a long-acting GLP-1/glucagon dual agonist, in obese individuals

On March 6, 2024, the patient was readmitted with new-onset seizures, which had been occurring for one month and culminated in status epilepticus

Then you add a GIP sequence to it

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Given the robustness of this mitochondrial response, the multifaceted nature of PGC1 regulation in cells and a modest rescue at best by mTORC1 inhibition, we suspect that there is a degree of functional redundancy built into this metabolic plasticity system that can contribute to such an adaptive response, and complete inhibition of this system will prove difficult