Appelqvist H, Waster P, Kagedal K, Ollinger K
Molecular pathways: A novel approach to targeting hypoxia and improving radiotherapy efficacy via reduction in oxygen demand
It does not affect metabolism or fat storage in a way that leads to weight gain
Concretely, artesunate, dihydroartemisinin, and artemether decrease the expression of tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-2 (IL-2), increase the expression of toll-like receptor 2 (TLR2), CD4 + T cells, and Interferon- (IFN-), inhibit inflammation, and enhance immunity, ultimately, the number of P
the compound's evidence base is limited to preclinical in vitro and animal (largely rodent) studies of IGF-1 receptor activation, muscle-cell signaling, and tissue repair, with human safety and efficacy data for this specific analog effectively absent