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doi: 10.1016/S0896-6273(00)80351-7 85 ZernRTBirdJLFeldmanJM

While the adverse event profile could be a concern to payers, at present the issues that influence their coverage decisions are mostly financial, including the budgetary impact of reimbursing drug costs for large numbers of patients with weight problems and the products lack of cost-effectiveness

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Most oral supplements range from 2501000 mg daily, though some practitioners recommend higher doses or alternative delivery methods for specific conditions