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Journal of the American Nutrition Association [Internet]

In order to elucidate the inhibition mechanism of HQ, we solved two crystal structures of TyrBm with HQ in the active site

Furthermore, several novel therapeutic compounds (GIP receptor antagonists and agonists including multiple-targeting compounds) have also shown beneficial glucometabolic and body weight lowering effects in individuals with type 2 diabetes and obesity (40, 41)

Nock, Nora L., et al

Limited clinical validation: Despite decades of research interest, DSIP has not progressed into wide-scale clinical adoption, which raises questions about consistency and reproducibility of effects