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Tesamorelin was engineered with a trans-3-hexenoic acid modification that protects it from DPP-IV degradation, extending its half-life from the ~7 minutes of native GHRH to approximately 26 minutes

Plasma GHK-Cu concentrations decline with age, from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60, correlating with reduced skin repair capacity

[DOI] [PubMed] [Google Scholar] 7.Ale F, Alves RC, Arajo JF, Azevedo A, Bacelar A, Bezerra M, et al