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Proc Natl Acad Sci U S A 115(8):E1896E1905

However, the treatment does not have to be FDA approved for us to know that the drug can be used safely

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For someone starting at 0.25 mg and planning to escalate to 1.0 mg: At 2.5 mg/mL: 0.25 mg = 10 units, 1.0 mg = 40 units (ideal range) At 5 mg/mL: 0.25 mg = 5 units, 1.0 mg = 20 units (workable but tight at low end) The 2.5 mg/mL option keeps all doses in a comfortable measurement range