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Serum data were modeled using D-Nle-Tyr-Ile-NH-(CH 2 ) 5 - CONH 2 appeared to be extensively distributed outside the central blood compartment and/or bound within the tissues as evidenced by its large volume of distribution (Vd)

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Experimental models have examined its influence on vascular endothelial growth factor receptor-2 (VEGFR2) signaling, including activation of downstream VEGFR2AkteNOS pathways associated with endothelial cell proliferation and vascular signaling processes

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