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Research shows that NAD+ levels can decline by as much as 50% as we age, leading to cognitive fatigue, brain fog, and low energy that get in the way of your full and healthy life

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Note that while elevated homocysteine is associated with an increased risk of Alzheimer's disease, systematic reviews of clinical trials comparing vitamin B12 supplementation to placebo groups have not shown a significant effect in preventing or slowing Alzheimer's disease or cognitive decline

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Whilst human studies demonstrating an impact on cognitive decline are still lacking, the current evidence points towards these drugs having a preventative effect, rather than in patients with established cognitive impairment