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The cosmetics industry faces many challenges, especially when boosting the permeation of cosmetically active compounds (CACs) through the skin is an issue

Probiotics: modulation of the gut microbiota (e.g., using Limosilactobacillus reuteri) has been associated with reduced SUA levels and decreased gout flare frequency (Rodriguez et al., 2023)

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A: The main reasons are limited drug-level clinical data, high FDA approval costs, and insufficient commercial incentives for pharmaceutical development

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