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In smokers volar forearm skin, we found increased epidermal differentiation, which may represent a compensatory mechanism induced as an adaptive response to environmental toxins such as PAHs present in cigarette smoke, or nicotine, both of which have the ability to stimulate keratinocyte differentiation

Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function

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Substance use disorder is characterized by symptoms such as withdrawal symptoms, increased tolerance, and compulsive drug-seeking behavior

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