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In the second step of biosynthesis, glutathione synthetase (GS) adds the final amino acid, glycine, to complete the glutathione molecule
Although we identified a likely link between the Na + and carnitine sites, further structural and functional investigations will be necessary to define the precise details of how coupling between the Na + binding and structural change at the carnitine-binding site is mediated
doi: 10.1186/1475-2867-8-10 132 NiuX-BFuG-BWangLGeXLiuW-TWenY-Yet al
Metabolic relevance: Provides insights into adipocyte function, fat storage, and energy balance
Considering the pivotal function of ferroptosis in OA, targets such as transient receptor potential vanilloid 1 (TRPV1) [27,28], glutathione peroxidase 4 (GPX4) [29], nuclear factor erythroid 2-related factor 2 (NRF2) [30], acyl-CoA synthetase long-chain family member 4 (ACSL4) [31], and nuclear coactivator adaptor 4 (NCOA4) [32] have surfaced as prospective regulators of ferroptosis and modulators of OA advancement
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