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Over the past decade, research efforts in tumor biology have highlighted the pivotal role of exosomal oncogenic proteins and RNAs to modulate the TME and support tumor progression [142,143,144]

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Clinical trials indicate that it takes approximately one to three months of continuous supplementation to achieve statistically significant elevations in deep tissue stores and to observe measurable improvements in immune cell cytotoxicity

Furthermore, heterogeneity in cytokine/chemokine profiles within the TME also matters