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Author: Eric Patterson, LPC (No change) Medical Reviewer: Benjamin Troy, MD (No change) Primary Changes: Reviewed entire article and revised where necessary to improve factual accuracy, clarity, and enhanced readability

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None of the three compounds have safety data in this context

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9 Local recurrences were noted in 29% of patients in one series of 58 desmoplastic and/or neurotropic melanomas, with a malignant cranial neuropathy occurring in four patients and death from metastatic disease in 19% of cases

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a sham procedure, a post hoc analysis revealed a large subgroup of "responders" in whom potential efficacy was demonstrated

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