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However, GHK with two net positive charges leads to lower cell membrane adsorption than the two chimeric peptides (Figure 3D)

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Additional studies have shown that LacCer activates cytosolic phospholipase A2 (PLA2) and MAV2 in astrocytes and that, autocrinely, this pathway leads to NFkB activation and transcription of inflammatory factors, contributing to the pathogenesis of EAE and MS