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The highest dose of retatrutide had almost three times the adverse-event discontinuation rate of the highest dose of tirzepatide

43 , 44 Under insulinresistant conditions, diminished IGF1 activity exacerbates neuronal energy deficits and promotes a proinflammatory phenotype in glial cells

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Consequently, pyridoxine significantly influences the adrenergic, serotonergic, and glutamatergic systems ( Pyridoxine may also exert a protective effect on the nervous system by regulating the glutamatergic system and thus modulating GABA and glutamate levels (60)