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In fact, brain is the organ containing the largest amount of DHA in the whole organism, and it seems that it was selected soon in the evolution of the cephalization process of vertebrates to provide a special biochemical microenvironment to nerve cell membranes, especially during the massive accretion in the evolution of primate brains (Crawford et al., 2011)

All evidence comes from mouse models and cell cultures

N Engl J Med 377:12281239 Lee YS, Jun HS (2016) Anti-Inflammatory Effects of GLP-1-based therapies beyond glucose control

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Food intake remained consistent between the groups, suggesting metabolic changes