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Weight gain was associated with increased osteoporosis risk among those not on a GLP-1, while weight gain was not associated with statistically significant change in osteoporosis risk for those on a GLP-1

When used together, these opposing effects on heart rate may partially offset each other, though beta blockers typically predominate in their chronotropic effects

It signals your brain to reduce appetite

GLP-1R activation provides anti-inflammatory, metabolic, cardiovascular, and neuroprotective properties [8]

This phenomenon is particularly pronounced in postmenopausal women, who demonstrate an elevated risk for hypertension, arrhythmias, and heart failure (52, 53)