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(E & F) The differentially-expressed genes upon auxin treatment for 48 hours were compared to putative LAG-1 targets through LAG-1 germline ChIP-seq analysis to determine the LAG-1 transcriptional targets (E) and if LAG-1 can repress gene expression (F)

Collectively, our results highlight the limitation of APR-246 as a p53-rescuing drug because of its overwhelming off-target effects on the redox system at doses that are sufficient to induce ferroptosis but insufficient to rescue mutant p53

This regimen is intended to support metabolism, digestion, nutrient sufficiency and be an adjunct or alternative to jumping straight into GLP-1 medication

The company also projected adjusted EBITDA of $270 million to $320 million

So why the significant price difference