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A: Yes, absolutely

Such drugs function as inhibitors, binding to the active site by mimicking the tetrahedral intermediate of its substrate, thus disabling the enzyme

Biochem Biokhimiia 70:200214 Adam-Vizi V, Chinopoulos C (2006) Bioenergetics and the formation of mitochondrial reactive oxygen species

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Our aim in this introduction is to provide insights into strategies for mitigating these limitations and optimizing ferroptosis-based cancer treatments