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The role of dorsomedial hypothalamus (DMH) glucagon-like peptide-1 receptor (GLP-1R) neurons regulating cognitive satiation can be likened to stepping on a vehicles brake in response to traffic signals - a preemptive action taken before reaching the actual stop goal, reflecting a feed-forward control mechanism

The GLP-1R, as an integral membrane protein and 7-TMD GPCR, tightly interacts with its lipid-rich plasma membrane microenvironment (51) and is also known to segregate to cholesterol-rich flotillin-positive lipid nanodomains upon activation (25)