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Description

As represented on an ECG, estrogen prolongs the QT interval while progesterone and testosterone shorten the QT interval

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Mechanistically, artemisinin and its derivatives directly target LONP1 in theca-interstitial cells, enhancing its interaction with cytochrome P450 family 11 subfamily A member 1 (CYP11A1) and promoting LONP1-catalyzed degradation of CYP11A1

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