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Reduced glutathione plays an important physiological role in organisms

There is probably a lacking variable in the elderly that makes them more vulnerable to the severity of disease

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier

Table S2 Barrier integrity for marker molecules fluorescein (SF) and albumin (EBA) after 24-h nanocarrier permeability assay

During the treatment, the IV drip typically takes 3045 minutes